Mobilising the Microbiome against the Coming Plague of Anti-Microbial Resistance
- Broad spectrum antibiotics damage the bacteria in our gut and can generate resistance in non-target species with significant implications for human health.
- Bacteria and viruses in the human gut are a source of new narrow spectrum antimicrobials.
- APC Microbiome Ireland is at the forefront in developing new treatments to replace broad spectrum antibiotics. These include narrow spectrum antimicrobials derived from bacteria and viruses in the gut, as well live bacteria, bacteriophages (viruses which kill bacteria), fungi and faecal microbiota transplants.
Resistance to antibiotics (antimicrobial resistance; AMR) is a global health threat and poses serious challenges for Irish and other national health systems. However, solutions are emerging. APC Microbiome Ireland, a world leading Science Foundation Ireland Research Institute, based at University College Cork and Teagasc, is at the forefront of research using bacteria and viruses found in our gut (the microbiome) to treat serious infections. International researchers are gathering in Cork today to discuss the latest developments, particularly those focusing on mobilising the microbiome.
Each year more than 700,000 people across the world die from infections that are resistant to current antibiotics, and by 2050 drug-resistant infections will take an estimated 10 million lives per year. The economic cost of lost global production caused by antimicrobial resistance will amount to approximately $100 trillion between now and 2050 if it is not tackled. Ireland has a relatively high rate of antimicrobial resistance in human health compared to most European countries, and ranks above the EU average for consumption of antibiotics in the community.
“There is about one new case of carbapenemase-producing enterobacteriaceae (CPE) found in Ireland everyday" said Martin Cormican, National Clinical Lead for Health Care Acquired Infections and Anti-Microbial Resistance and keynote speaker at the conference. “Antibiotic resistant bacteria, sometimes called superbugs, are already causing serious illness, shortening lives and increasing health care costs. If we do not manage these better than we have in the past, antibiotic resistant bacteria may undermine the sustainability of the entire healthcare system. CPE was declared a public health emergency in Ireland on 25th of October 2017 but so far, about 3 months into this emergency, we are not making progress as quickly as we need to if we are to control this.”
The increasing number of bacterial species resistant to antibiotics is both inevitable and predictable, so with increasing amounts of data we can and must start to plan for the future and to develop new strategies to prevent the spread of AMR, and alternative therapeutics to treat antimicrobial resistant infections.
"Mobilising the microbiome will have a central role in future strategies against infections".
“Broad spectrum antibiotics, which target a broad range of bacterial species, cause collateral damage to the gut microbiome, which is so important to health, and also generate resistance in non-target species with implications for human health” said Colin Hill, SFI Research Centre APC Microbiome Ireland, UCC. “We are at the forefront of research mining the human microbiome to develop new narrow spectrum antimicrobials that only kill the target species. These will limit resistance in non-target species and the resulting damage to human health. We are also developing live therapeutic bacteria, bacteriophages (viruses which kill bacteria) and faecal microbiota transplants as alternative therapeutics to antibiotics.”
“The use of antibiotics in Ireland during the period 2012 to 2016 continued to rise and Ireland, along with Belgium and France, is a higher consumer of antimicrobials relative to other EU countries” said Stephen Byrne, Head of School of Pharmacy, UCC. “Irish studies have reported the overuse of antimicrobials in primary care, even when clinicians deem their use to be unnecessary, and have reported that clinicians feel pressurised by patients to prescribe antimicrobials.”
Graham Rook, University College London, pointed out the importance of hygiene as an effective anti-microbial strategy and contrary to the so-called ‘hygiene hypothesis’ he showed that ancestral microbes or ‘old friends’ are necessary for training and development of the human immune system.
“The public health message on antibiotics needs to be refined. In addition to minimising unnecessary and inappropriate use, the public needs to know that broad spectrum antibiotics damage beneficial as well as harmful bacteria. Moreover, mobilising the microbiome will have a central role in future strategies against infections” said Fergus Shanahan, Director of SFI Research Centre APC Microbiome Ireland, and Chief Clinical Director of the HSE South/Southwest Hospital Group.